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Effect of dC → d(m(5)C) Substitutions on the Folding of Intramolecular Triplexes with Mixed TAT and C(+)GC Base Triplets

Oligonucleotide-directed triple helix formation has been recognized as a potential tool for targeting genes with high specificity. Cystosine methylation in the 5′ position is both ubiquitous and a stable regulatory modification, which could potentially stabilize triple helix formation. In this work,...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biochimie
Prif Awduron: Carr, Carolyn E., Ganugula, Rajkumar, Shikiya, Ronald, Soto, Ana Maria, Marky, Luis A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5811340/
https://ncbi.nlm.nih.gov/pubmed/29277568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biochi.2017.12.008
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