RHOA G17V induces T follicular helper cell specification and promotes lymphomagenesis

Angioimmunoblastic T cell lymphoma (AITL) is an aggressive tumor derived from malignant transformation of T follicular helper (Tfh) cells. AITL is characterized by loss-of-function mutations in Ten-Eleven Translocation 2 (TET2) epigenetic tumor suppressor and a highly recurrent mutation (p.Gly17Val)...

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Détails bibliographiques
Publié dans:Cancer Cell
Auteurs principaux: Cortes, Jose R., Ambesi-Impiombato, Alberto, Couronné, Lucile, Quinn, S. Aidan, Kim, Christine S., da Silva Almeida, Ana Carolina, West, Zachary, Belver, Laura, Martin, Marta Sanchez, Scourzic, Laurianne, Bhagat, Govind, Bernard, Olivier A., Ferrando, Adolfo, Palomero, Teresa
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5811310/
https://ncbi.nlm.nih.gov/pubmed/29398449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.01.001
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