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Evolutionary analysis of polyproline motifs in Escherichia coli reveals their regulatory role in translation

Translation of consecutive prolines causes ribosome stalling, which is alleviated but cannot be fully compensated by the elongation factor P. However, the presence of polyproline motifs in about one third of the E. coli proteins underlines their potential functional importance, which remains largely...

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Veröffentlicht in:PLoS Comput Biol
Hauptverfasser: Qi, Fei, Motz, Magdalena, Jung, Kirsten, Lassak, Jürgen, Frishman, Dmitrij
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5811046/
https://ncbi.nlm.nih.gov/pubmed/29389943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005987
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