Transcription factors orchestrate dynamic interplay between genome topology and gene regulation during cell reprogramming

Chromosomal architecture is known to influence gene expression, yet its role in controlling cell fate remains poorly understood. Reprogramming of somatic cells into pluripotent stem cells by the transcription factors (TFs) Oct4, Sox2, Klf4 and Myc offers an opportunity to address this question but i...

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Vydáno v:Nat Genet
Hlavní autoři: Stadhouders, Ralph, Vidal, Enrique, Serra, François, Di Stefano, Bruno, Le Dily, François, Quilez, Javier, Gomez, Antonio, Collombet, Samuel, Berenguer, Clara, Cuartero, Yasmina, Hecht, Jochen, Filion, Guillaume J., Beato, Miguel, Marti-Renom, Marc A., Graf, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5810905/
https://ncbi.nlm.nih.gov/pubmed/29335546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-017-0030-7
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