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Small-molecule inhibitors of Wnt signaling pathway: towards novel anticancer therapeutics

BACKGROUND: The Wnt signaling pathway involves secreted glycoproteins that bind to the Frizzled family receptors to activate intracellular signal transduction events that regulate cell proliferation, apoptosis, cell migration and many critical aspects of developmental biology. DISCUSSION: Aberrant W...

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Veröffentlicht in:Future Med Chem
Hauptverfasser: Zheng, Shilong, Liu, Jiawang, Wu, Yanyuan, Huang, Tien L, Wang, Guangdi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Future Science Ltd 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5810846/
https://ncbi.nlm.nih.gov/pubmed/26670195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/fmc.15.159
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