Senescent T-Cells Promote Bone Loss in Rheumatoid Arthritis

OBJECTIVE: T-cells are critical players in the pathogenesis of osteoporosis in patients with rheumatoid arthritis (RA). Premature senescence of lymphocytes including the accumulation of senescent CD4(+) T-cells is a hallmark feature of RA. Whether T-cell senescence is associated with bone loss in RA...

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Udgivet i:Front Immunol
Main Authors: Fessler, Johannes, Husic, Rusmir, Schwetz, Verena, Lerchbaum, Elisabeth, Aberer, Felix, Fasching, Patrizia, Ficjan, Anja, Obermayer-Pietsch, Barbara, Duftner, Christina, Graninger, Winfried, Stradner, Martin Helmut, Dejaco, Christian
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5810289/
https://ncbi.nlm.nih.gov/pubmed/29472917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00095
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