Histone deacetylase-4 and histone deacetylase-8 regulate interleukin-1β-induced cartilage catabolic degradation through MAPK/JNK and ERK pathways

Interleukin-1β (IL-1β)-induced inflammatory response is associated with osteoarthritis (OA) and its development. Histone deacetylase (HDAC) may be involved in regulating this pathogenesis, but the mechanism has yet to be elucidated. The aim of the present study was to investigate the mechanism under...

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Pubblicato in:Int J Mol Med
Autori principali: Wang, Pengcheng, Mao, Zekai, Pan, Qiyong, Lu, Rui, Huang, Xiaojian, Shang, Xiaobin, Zhang, Rui, You, Hongbo
Natura: Artigo
Lingua:Inglês
Pubblicazione: D.A. Spandidos 2018
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5810207/
https://ncbi.nlm.nih.gov/pubmed/29393346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijmm.2018.3410
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