Identification of Novel Structural Determinants in MW965 Env That Regulate the Neutralization Phenotype and Conformational Masking Potential of Primary HIV-1 Isolates

The subtype C HIV-1 isolate MW965.26 is a highly neutralization-sensitive tier 1a primary isolate that is widely used in vaccine studies, but the basis for the sensitive neutralization phenotype of this isolate is not known. Substituting the MW965.26 V1/V2 domain into a neutralization-sensitive SF16...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Qualls, Zakiya M., Choudhary, Alok, Honnen, William, Prattipati, Raja, Robinson, James E., Pinter, Abraham
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5809737/
https://ncbi.nlm.nih.gov/pubmed/29237828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01779-17
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