Early Actions of Anti–Vascular Endothelial Growth Factor/Vascular Endothelial Growth Factor Receptor Drugs on Angiogenic Blood Vessels

Tumors induce their heterogeneous vasculature by secreting vascular endothelial growth factor (VEGF)-A. Anti-VEGF/VEGF receptor (VEGFR) drugs treat cancer, but the underlying mechanisms remain unclear. An adenovirus expressing VEGF-A (Ad-VEGF-A(164)) replicates the tumor vasculature in mice without...

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Udgivet i:Am J Pathol
Main Authors: Sitohy, Basel, Chang, Sunghee, Sciuto, Tracey E., Masse, Elizabeth, Shen, Mei, Kang, Peter M., Jaminet, Shou-Ching, Benjamin, Laura E., Bhatt, Rupal S., Dvorak, Ann M., Nagy, Janice A., Dvorak, Harold F.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5809587/
https://ncbi.nlm.nih.gov/pubmed/28736316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2017.06.010
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