The NLRP3 Inflammasome May Contribute to Pathologic Neovascularization in the Advanced Stages of Diabetic Retinopathy

Diabetic retinopathy (DR) is a retinal microvascular disease characterized by inflammatory and angiogenic pathways. In this study, we evaluated NLRP3 inflammasome in a double transgenic mouse model, Akimba (Ins2(Akita)xVEGF(+/−)), which demonstrates hyperglycemia, vascular hyperpermeability and neov...

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Gepubliceerd in:Sci Rep
Hoofdauteurs: Chaurasia, Shyam S., Lim, Rayne R., Parikh, Bhav H., Wey, Yeo Sia, Tun, Bo Bo, Wong, Tien Yin, Luu, Chi D., Agrawal, Rupesh, Ghosh, Arkasubhra, Mortellaro, Alessandra, Rackoczy, Elizabeth, Mohan, Rajiv R., Barathi, Veluchamy A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5809448/
https://ncbi.nlm.nih.gov/pubmed/29434227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-21198-z
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