Eliminating Factor H-Binding Activity of Borrelia burgdorferi CspZ Combined with Virus-Like Particle Conjugation Enhances Its Efficacy as a Lyme Disease Vaccine

The spirochete Borrelia burgdorferi is the causative agent of Lyme disease, the most common tick-borne disease in the US and Europe. No potent human vaccine is currently available. The innate immune complement system is vital to host defense against pathogens, as complement activation on the surface...

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Détails bibliographiques
Publié dans:Front Immunol
Auteurs principaux: Marcinkiewicz, Ashley L., Lieknina, Ilva, Kotelovica, Svetlana, Yang, Xiuli, Kraiczy, Peter, Pal, Utpal, Lin, Yi-Pin, Tars, Kaspars
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2018
Sujets:
Immunology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5809437/
https://ncbi.nlm.nih.gov/pubmed/29472926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00181
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