Macrogenomic engineering via modulation of the scaling of chromatin packing density

Many human diseases result from the dysregulation of the complex interactions between tens to thousands of genes. However, approaches for the transcriptional modulation of many genes simultaneously in a predictive manner are lacking. Here, through the combination of simulations, systems modelling an...

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Pubblicato in:Nat Biomed Eng
Autori principali: Almassalha, Luay M., Bauer, Greta M., Wu, Wenli, Cherkezyan, Lusik, Zhang, Di, Kendra, Alexis, Gladstein, Scott, Chandler, John E., VanDerway, David, Seagle, Brandon-Luke L., Ugolkov, Andrey, Billadeau, Daniel D., O’Halloran, Thomas V., Mazar, Andrew P., Roy, Hemant K., Szleifer, Igal, Shahabi, Shohreh, Backman, Vadim
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5809134/
https://ncbi.nlm.nih.gov/pubmed/29450107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41551-017-0153-2
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