Macrogenomic engineering via modulation of the scaling of chromatin packing density

Many human diseases result from the dysregulation of the complex interactions between tens to thousands of genes. However, approaches for the transcriptional modulation of many genes simultaneously in a predictive manner are lacking. Here, through the combination of simulations, systems modelling an...

詳細記述

保存先:
書誌詳細
出版年:Nat Biomed Eng
主要な著者: Almassalha, Luay M., Bauer, Greta M., Wu, Wenli, Cherkezyan, Lusik, Zhang, Di, Kendra, Alexis, Gladstein, Scott, Chandler, John E., VanDerway, David, Seagle, Brandon-Luke L., Ugolkov, Andrey, Billadeau, Daniel D., O’Halloran, Thomas V., Mazar, Andrew P., Roy, Hemant K., Szleifer, Igal, Shahabi, Shohreh, Backman, Vadim
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5809134/
https://ncbi.nlm.nih.gov/pubmed/29450107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41551-017-0153-2
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