Macrogenomic engineering via modulation of the scaling of chromatin packing density

Many human diseases result from the dysregulation of the complex interactions between tens to thousands of genes. However, approaches for the transcriptional modulation of many genes simultaneously in a predictive manner are lacking. Here, through the combination of simulations, systems modelling an...

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Detalhes bibliográficos
Publicado no:Nat Biomed Eng
Main Authors: Almassalha, Luay M., Bauer, Greta M., Wu, Wenli, Cherkezyan, Lusik, Zhang, Di, Kendra, Alexis, Gladstein, Scott, Chandler, John E., VanDerway, David, Seagle, Brandon-Luke L., Ugolkov, Andrey, Billadeau, Daniel D., O’Halloran, Thomas V., Mazar, Andrew P., Roy, Hemant K., Szleifer, Igal, Shahabi, Shohreh, Backman, Vadim
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5809134/
https://ncbi.nlm.nih.gov/pubmed/29450107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41551-017-0153-2
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