Knockdown of L1CAM significantly reduces metastasis in a xenograft model of human melanoma: L1CAM is a potential target for anti-melanoma therapy

Finding additional functional targets for combination therapy could improve the outcome for melanoma patients. In a spontaneous metastasis xenograft model of human melanoma a shRNA mediated knockdown of L1CAM more than sevenfold reduced the number of lung metastases after the induction of subcutaneo...

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Pubblicato in:PLoS One
Autori principali: Ernst, Ann-Kathrin, Putscher, Annika, Samatov, Timur R., Suling, Anna, Galatenko, Vladimir V., Shkurnikov, Maxim Yu, Knyazev, Evgeny N., Tonevitsky, Alexander G., Haalck, Thomas, Lange, Tobias, Maar, Hanna, Schröder- Schwarz, Jennifer, Riecken, Kristoffer, Schumacher, Udo, Wicklein, Daniel
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5809060/
https://ncbi.nlm.nih.gov/pubmed/29432466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0192525
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