Histone deacetylase inhibitor entinostat (MS-275) restores anesthesia-induced alteration of inhibitory synaptic transmission in the developing rat hippocampus

Recent evidence strongly supports the idea that common general anesthetics (GAs) such as isoflurane (Iso) and nitrous oxide (N(2)O; laughing gas), as well as sedative drugs such midazolam are neurotoxic for the developing mammalian brain having deleterious effects on neural circuits involved in cogn...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Neurobiol
Hauptverfasser: Joksimovic, Srdjan M., Osuru, Hari Prasad, Oklopcic, Azra, Beenhakker, Mark P., Jevtovic-Todorovic, Vesna, Todorovic, Slobodan M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808908/
https://ncbi.nlm.nih.gov/pubmed/28840475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-017-0735-8
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