Phosphate (P(i))-regulated heterodimerization of the high-affinity sodium-dependent P(i) transporters PiT1/Slc20a1 and PiT2/Slc20a2 underlies extracellular P(i) sensing independently of P(i) uptake

Extracellular phosphate (P(i)) can act as a signaling molecule that directly alters gene expression and cellular physiology. The ability of cells or organisms to detect changes in extracellular P(i) levels implies the existence of a P(i)-sensing mechanism that signals to the body or individual cell....

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Bon, Nina, Couasnay, Greig, Bourgine, Annabelle, Sourice, Sophie, Beck-Cormier, Sarah, Guicheux, Jérôme, Beck, Laurent
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2018
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808770/
https://ncbi.nlm.nih.gov/pubmed/29233890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.807339
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