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Genome-editing applications of CRISPR–Cas9 to promote in vitro studies of Alzheimer’s disease
Genetic variations play an important role in the clinical presentation and progression of Alzheimer’s disease (AD), especially early-onset Alzheimer’s disease. Hundreds of mutations have been reported with the majority resulting from alterations in β-amyloid precursor protein (APP), presenilin 1 (PS...
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| Publié dans: | Clin Interv Aging |
|---|---|
| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Dove Medical Press
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5808714/ https://ncbi.nlm.nih.gov/pubmed/29445268 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CIA.S155145 |
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