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A novel eight amino acid insertion contributes to the hemagglutinin cleavability and the virulence of a highly pathogenic avian influenza A (H7N3) virus in mice

In 2012, an avian influenza A H7N3 (A/Mexico/InDRE7218/2012; Mx/7218) virus was responsible for two confirmed cases of human infection and led to the death or culling of more than 22 million chickens in Jalisco, Mexico. Interestingly, this virus acquired an 8-amino acid (aa)-insertion (..PENPK-DRKSR...

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Detalhes bibliográficos
Publicado no:Virology
Main Authors: Sun, Xiangjie, Belser, Jessica A., Tumpey, Terrence M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808403/
https://ncbi.nlm.nih.gov/pubmed/26629952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2015.10.032
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