Identification of key hemagglutinin residues responsible for cleavage, acid stability, and virulence of fifth-wave highly pathogenic avian influenza A(H7N9) viruses

We previously demonstrated that despite no airborne transmissibility increase compared to low pathogenic avian influenza viruses, select human isolates of highly pathogenic avian influenza A(H7N9) virus exhibit greater virulence in animal models and a lower threshold pH for fusion. In the current st...

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Enregistré dans:
Détails bibliographiques
Publié dans:Virology
Auteurs principaux: Sun, Xiangjie, Belser, Jessica A., Yang, Hua, Pulit-Penaloza, Joanna A., Pappas, Claudia, Brock, Nicole, Zeng, Hui, Creager, Hannah M., Stevens, James, Maines, Taronna R.
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7263870/
https://ncbi.nlm.nih.gov/pubmed/31325838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2019.07.012
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