Identification of key hemagglutinin residues responsible for cleavage, acid stability, and virulence of fifth-wave highly pathogenic avian influenza A(H7N9) viruses

We previously demonstrated that despite no airborne transmissibility increase compared to low pathogenic avian influenza viruses, select human isolates of highly pathogenic avian influenza A(H7N9) virus exhibit greater virulence in animal models and a lower threshold pH for fusion. In the current st...

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Veröffentlicht in:Virology
Hauptverfasser: Sun, Xiangjie, Belser, Jessica A., Yang, Hua, Pulit-Penaloza, Joanna A., Pappas, Claudia, Brock, Nicole, Zeng, Hui, Creager, Hannah M., Stevens, James, Maines, Taronna R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7263870/
https://ncbi.nlm.nih.gov/pubmed/31325838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2019.07.012
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