Structural Immaturity of Human iPSC-Derived Cardiomyocytes: In Silico Investigation of Effects on Function and Disease Modeling

Background: Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have emerged as a promising experimental tool for translational heart research and drug development. However, their usability as a human adult cardiomyocyte model is limited by their functional immaturity. Our aim is...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Koivumäki, Jussi T., Naumenko, Nikolay, Tuomainen, Tomi, Takalo, Jouni, Oksanen, Minna, Puttonen, Katja A., Lehtonen, Šárka, Kuusisto, Johanna, Laakso, Markku, Koistinaho, Jari, Tavi, Pasi
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808345/
https://ncbi.nlm.nih.gov/pubmed/29467678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.00080
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