The Plasma Kallikrein–Kininogen Pathway Is Critical in the Pathogenesis of Colitis in Mice

The kallikrein–kinin system (KKS) consists of two serine proteases, prekallikrein (pKal) and factor XII (FXII), and a cofactor, high-molecular-weight kininogen (HK). Upon activation of the KKS, HK is cleaved to release bradykinin. Although the KKS is activated in humans and animals with inflammatory...

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Bibliografiske detaljer
Udgivet i:Front Immunol
Main Authors: Wang, Bo, Yang, Aizhen, Zhao, Zhenzhen, He, Chao, Liu, Yuanyuan, Colman, Robert W., Dai, Jihong, Wu, Yi
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808240/
https://ncbi.nlm.nih.gov/pubmed/29467753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00021
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