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The Plasma Kallikrein–Kininogen Pathway Is Critical in the Pathogenesis of Colitis in Mice
The kallikrein–kinin system (KKS) consists of two serine proteases, prekallikrein (pKal) and factor XII (FXII), and a cofactor, high-molecular-weight kininogen (HK). Upon activation of the KKS, HK is cleaved to release bradykinin. Although the KKS is activated in humans and animals with inflammatory...
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| Publicado no: | Front Immunol |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5808240/ https://ncbi.nlm.nih.gov/pubmed/29467753 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00021 |
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