Whole-genome sequencing of chronic lymphocytic leukaemia reveals distinct differences in the mutational landscape between IgHV(mut) and IgHV(unmut) subgroups

Chronic lymphocytic leukaemia (CLL) consists of two biologically and clinically distinct subtypes defined by the abundance of somatic hypermutation (SHM) affecting the Ig variable heavy-chain locus (IgHV). The molecular mechanisms underlying these subtypes are incompletely understood. Here, we prese...

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Bibliographic Details
Published in:Leukemia
Main Authors: Burns, A, Alsolami, R, Becq, J, Stamatopoulos, B, Timbs, A, Bruce, D, Robbe, P, Vavoulis, D, Clifford, R, Cabes, M, Dreau, H, Taylor, J, Knight, S J L, Mansson, R, Bentley, D, Beekman, R, Martín-Subero, J I, Campo, E, Houlston, R S, Ridout, K E, Schuh, A
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2018
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808074/
https://ncbi.nlm.nih.gov/pubmed/28584254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2017.177
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