Whole-genome sequencing of chronic lymphocytic leukaemia reveals distinct differences in the mutational landscape between IgHV(mut) and IgHV(unmut) subgroups

Chronic lymphocytic leukaemia (CLL) consists of two biologically and clinically distinct subtypes defined by the abundance of somatic hypermutation (SHM) affecting the Ig variable heavy-chain locus (IgHV). The molecular mechanisms underlying these subtypes are incompletely understood. Here, we prese...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Leukemia
Prif Awduron: Burns, A, Alsolami, R, Becq, J, Stamatopoulos, B, Timbs, A, Bruce, D, Robbe, P, Vavoulis, D, Clifford, R, Cabes, M, Dreau, H, Taylor, J, Knight, S J L, Mansson, R, Bentley, D, Beekman, R, Martín-Subero, J I, Campo, E, Houlston, R S, Ridout, K E, Schuh, A
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2018
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808074/
https://ncbi.nlm.nih.gov/pubmed/28584254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2017.177
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