The interaction between androgen receptor and semenogelin I: a synthetic LxxLL peptide antagonist inhibits the growth of prostate cancer cells

BACKGROUND: We previously demonstrated that a seminal plasma protein, semenogelin I (SgI), functioned as an androgen receptor (AR) coactivator. Meanwhile, several short sequence motifs in AR coregulators, such as LxxLL (L=leucine), have been shown to mediate specific interactions with AR. METHODS: W...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Li, Peng, Chen, Jinbo, Kashiwagi, Eiji, Mizushima, Taichi, Han, Bin, Inoue, Satoshi, Ide, Hiroki, Izumi, Koji, Miyamoto, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2018
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808024/
https://ncbi.nlm.nih.gov/pubmed/29136406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2017.404
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