Structural basis for hijacking of cellular LxxLL motifs by papillomavirus E6 oncoproteins

E6 viral oncoproteins are key players in epithelial tumors induced by Papillomaviruses in vertebrates, including cervical cancer in humans. E6 proteins target many host proteins by specifically interacting with acidic LxxLL motifs. Here, we solved the crystal structures of Bovine (BPV1) and Human (H...

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Hauptverfasser: Zanier, Katia, Charbonnier, Sebastian, Sidi, Abdellahi Ould M’hamed Ould, McEwen, Alastair G., Ferrario, Maria Giovanna, Poussin, Pierre, Cura, Vincent, Brimer, Nicole, Babah, Khaled Ould, Ansari, Tina, Muller, Isabelle, Stote, Roland H., Cavarelli, Jean, Pol, Scott Vande, Travé, Gilles
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3899395/
https://ncbi.nlm.nih.gov/pubmed/23393263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1229934
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