Structural basis for hijacking of cellular LxxLL motifs by papillomavirus E6 oncoproteins

E6 viral oncoproteins are key players in epithelial tumors induced by Papillomaviruses in vertebrates, including cervical cancer in humans. E6 proteins target many host proteins by specifically interacting with acidic LxxLL motifs. Here, we solved the crystal structures of Bovine (BPV1) and Human (H...

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Bibliografische gegevens
Hoofdauteurs: Zanier, Katia, Charbonnier, Sebastian, Sidi, Abdellahi Ould M’hamed Ould, McEwen, Alastair G., Ferrario, Maria Giovanna, Poussin, Pierre, Cura, Vincent, Brimer, Nicole, Babah, Khaled Ould, Ansari, Tina, Muller, Isabelle, Stote, Roland H., Cavarelli, Jean, Pol, Scott Vande, Travé, Gilles
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3899395/
https://ncbi.nlm.nih.gov/pubmed/23393263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1229934
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