Potent Inhibitors of Hepatitis C Virus NS3 Protease: Employment of a Difluoromethyl Group as a Hydrogen-Bond Donor

[Image: see text] The design and synthesis of potent, tripeptidic acylsulfonamide inhibitors of HCV NS3 protease that contain a difluoromethyl cyclopropyl amino acid at P1 are described. A cocrystal structure of 18 with a NS3/4A protease complex suggests the presence of a H-bond between the polarize...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Zheng, Barbara, D’Andrea, Stanley V., Sun, Li-Qiang, Wang, Alan Xiangdong, Chen, Yan, Hrnciar, Peter, Friborg, Jacques, Falk, Paul, Hernandez, Dennis, Yu, Fei, Sheaffer, Amy K., Knipe, Jay O., Mosure, Kathy, Rajamani, Ramkumar, Good, Andrew C., Kish, Kevin, Tredup, Jeffrey, Klei, Herbert E., Paruchuri, Manjula, Ng, Alicia, Gao, Qi, Rampulla, Richard A., Mathur, Arvind, Meanwell, Nicholas A., McPhee, Fiona, Scola, Paul M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5807875/
https://ncbi.nlm.nih.gov/pubmed/29456803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00503
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