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Click-Addressable Cassette for Photoaffinity Labeling
[Image: see text] A small molecule 1 was designed to contain an alkyne, a trifluoromethyl phenyldiazirine, and a free piperidine-NH for facile conjugation to protein binding ligands. This “cassette” 1 was synthesized via a relatively direct route involving only routine steps. In this proof-of-concep...
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| Publicat a: | ACS Med Chem Lett |
|---|---|
| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Chemical
Society
2018
|
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5807873/ https://ncbi.nlm.nih.gov/pubmed/29456805 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00516 |
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