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Click-Addressable Cassette for Photoaffinity Labeling

[Image: see text] A small molecule 1 was designed to contain an alkyne, a trifluoromethyl phenyldiazirine, and a free piperidine-NH for facile conjugation to protein binding ligands. This “cassette” 1 was synthesized via a relatively direct route involving only routine steps. In this proof-of-concep...

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Dades bibliogràfiques
Publicat a:ACS Med Chem Lett
Autors principals: Zhao, Bosheng, Burgess, Kevin
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2018
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5807873/
https://ncbi.nlm.nih.gov/pubmed/29456805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00516
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