Discovery and in Vitro Optimization of 3-Sulfamoylbenzamides as ROMK Inhibitors

[Image: see text] Inhibitors of the renal outer medullary potassium channel (ROMK) show promise as novel mechanism diuretics, with potentially lower risk of diuretic-induced hypokalemia relative to current thiazide and loop diuretics. Here, we report the identification of a novel series of 3-sulfamo...

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書誌詳細
出版年:ACS Med Chem Lett
主要な著者: Sammons, Matthew F., Kharade, Sujay V., Filipski, Kevin J., Boehm, Markus, Smith, Aaron C., Shavnya, Andre, Fernando, Dilinie P., Dowling, Matthew S., Carpino, Philip A., Castle, Neil A., Zellmer, Shannon G., Antonio, Brett M., Gosset, James R., Carlo, Anthony, Denton, Jerod S.
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2018
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5807870/
https://ncbi.nlm.nih.gov/pubmed/29456800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00481
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