Discovery and in Vitro Optimization of 3-Sulfamoylbenzamides as ROMK Inhibitors

[Image: see text] Inhibitors of the renal outer medullary potassium channel (ROMK) show promise as novel mechanism diuretics, with potentially lower risk of diuretic-induced hypokalemia relative to current thiazide and loop diuretics. Here, we report the identification of a novel series of 3-sulfamo...

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Publié dans:ACS Med Chem Lett
Auteurs principaux: Sammons, Matthew F., Kharade, Sujay V., Filipski, Kevin J., Boehm, Markus, Smith, Aaron C., Shavnya, Andre, Fernando, Dilinie P., Dowling, Matthew S., Carpino, Philip A., Castle, Neil A., Zellmer, Shannon G., Antonio, Brett M., Gosset, James R., Carlo, Anthony, Denton, Jerod S.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2018
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5807870/
https://ncbi.nlm.nih.gov/pubmed/29456800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00481
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