Ablating both Fabp1 and Scp2/Scpx (TKO) Induces Hepatic Phospholipid and Cholesterol Accumulation in High Fat-fed Mice

Although singly ablating Fabp1 or Scp2/Scpx genes may exacerbate the impact of high fat diet (HFD) on whole body phenotype and non-alcoholic fatty liver disease (NAFLD), concomitant upregulation of the non-ablated gene, preference for ad libitum fed HFD, and sex differences complicate interpretation...

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Publicado en:Biochim Biophys Acta
Autores principales: Milligan, Sherrelle, Martin, Gregory G., Landrock, Danilo, McIntosh, Avery L., Mackie, John T., Schroeder, Friedhelm, Kier, Ann B.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5807141/
https://ncbi.nlm.nih.gov/pubmed/29307784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2017.12.013
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