Protein Phosphatase Inhibitor-1 Gene Therapy in a Swine Model of Nonischemic Heart Failure

BACKGROUND: Increased protein phosphatase-1 (PP1) in heart failure (HF) induces molecular changes deleterious to the cardiac cell. Inhibiting PP1 through the overexpression of a constitutively active inhibitor-1 (I-1c) has been shown to reverse cardiac dysfunction in a model of ischemic HF. OBJECTIV...

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Publicado no:J Am Coll Cardiol
Main Authors: Watanabe, Shin, Ishikawa, Kiyotake, Fish, Kenneth, Oh, Jae Gyun, Motloch, Lukas J., Kohlbrenner, Erik, Lee, Philyoung, Xie, Chaoqin, Lee, Ahyoung, Liang, Lifan, Kho, Changwon, Leonardson, Lauren, McIntyre, Maritza, Wilson, Scott, Samulski, R. Jude, Kranias, Evangelia, Weber, Thomas, Akar, Fadi G., Hajjar, Roger J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5807083/
https://ncbi.nlm.nih.gov/pubmed/28958332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2017.08.013
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