Sodium channel current loss of function in induced pluripotent stem cell-derived cardiomyocytes from a Brugada syndrome patient

Brugada syndrome predisposes to sudden death due to disruption of normal cardiac ion channel function, yet our understanding of the underlying cellular mechanisms is incomplete. Commonly used heterologous expression models lack many characteristics of native cardiomyocytes and, in particular, the in...

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Publicat a:J Mol Cell Cardiol
Autors principals: Selga, Elisabet, Sendfeld, Franziska, Martinez-Moreno, Rebecca, Medine, Claire N., Tura-Ceide, Olga, Wilmut, Sir Ian, Pérez, Guillermo J., Scornik, Fabiana S., Brugada, Ramon, Mills, Nicholas L.
Format: Artigo
Idioma:Inglês
Publicat: Academic Press 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5807028/
https://ncbi.nlm.nih.gov/pubmed/29024690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2017.10.002
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