Development of a RSK Inhibitor as a Novel Therapy for Triple Negative Breast Cancer

Metastatic breast cancer is an incurable disease and identification of novel therapeutic opportunities is vital. Triple negative breast cancer (TNBC) frequently metastasizes and high levels of activated RSK, a downstream MEK-ERK1/2 effector, are found in TNBC. We demonstrate using direct pharmacolog...

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Udgivet i:Mol Cancer Ther
Main Authors: Ludwik, Katarzyna A., Campbell, James P., Li, Mingzong, Li, Yu, Sandusky, Zachary M., Pasic, Lejla, Sowder, Miranda E., Brenin, David R., Pietenpol, Jennifer A., O’Doherty, George A., Lannigan, Deborah A.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5807013/
https://ncbi.nlm.nih.gov/pubmed/27528706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0106
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