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Expanding Proteoform Identifications in Top-Down Proteomic Analyses by Constructing Proteoform Families

In top-down proteomics, intact proteins are analyzed by tandem mass spectrometry and proteoforms, which are defined forms of a protein with specific sequences of amino acids and localized post-translational modifications, are identified using precursor mass and fragmentation data. Many proteoforms t...

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Foilsithe in:Anal Chem
Main Authors: Schaffer, Leah V., Shortreed, Michael R., Cesnik, Anthony J., Frey, Brian L., Solntsev, Stefan K., Scalf, Mark, Smith, Lloyd M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5807004/
https://ncbi.nlm.nih.gov/pubmed/29227670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.7b04221
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