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Metabolic plasticity in synthetic lethal mutants: Viability at higher cost
The most frequent form of pairwise synthetic lethality (SL) in metabolic networks is known as plasticity synthetic lethality. It occurs when the simultaneous inhibition of paired functional and silent metabolic reactions or genes is lethal, while the default of the functional partner is backed up by...
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| Publicado no: | PLoS Comput Biol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5806928/ https://ncbi.nlm.nih.gov/pubmed/29381693 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005949 |
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