Intragenic DNA methylation of PITX1 and the adjacent long non-coding RNA C5orf66-AS1 are prognostic biomarkers in patients with head and neck squamous cell carcinomas

BACKGROUND: Patients with squamous cell cancer of the head and neck region (HNSCC) are at risk for disease recurrence and metastases, even after initial successful therapy. A tissue-based biomarker could be beneficial to guide treatment as well as post-treatment surveillance. Gene methylation status...

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Pubblicato in:PLoS One
Autori principali: Sailer, Verena, Charpentier, Arthur, Dietrich, Joern, Vogt, Timo J., Franzen, Alina, Bootz, Friedrich, Dietrich, Dimo, Schroeck, Andreas
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5806891/
https://ncbi.nlm.nih.gov/pubmed/29425237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0192742
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