KRIT1 loss-of-function induces a chronic Nrf2-mediated adaptive homeostasis that sensitizes cells to oxidative stress: Implication for Cerebral Cavernous Malformation disease

KRIT1 (CCM1) is a disease gene responsible for Cerebral Cavernous Malformations (CCM), a major cerebrovascular disease of proven genetic origin affecting 0.3–0.5% of the population. Previously, we demonstrated that KRIT1 loss-of-function is associated with altered redox homeostasis and abnormal acti...

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Published in:Free Radic Biol Med
Main Authors: Antognelli, Cinzia, Trapani, Eliana, Delle Monache, Simona, Perrelli, Andrea, Daga, Martina, Pizzimenti, Stefania, Barrera, Giuseppina, Cassoni, Paola, Angelucci, Adriano, Trabalzini, Lorenza, Talesa, Vincenzo Nicola, Goitre, Luca, Retta, Saverio Francesco
Format: Artigo
Language:Inglês
Published: Elsevier Science 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5806631/
https://ncbi.nlm.nih.gov/pubmed/29170092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2017.11.014
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