Anti-CD11b antibody treatment suppresses the osteoclast generation, inflammatory cell infiltration, and autoantibody production in arthritis-prone FcγRIIB-deficient mice

BACKGROUND: Previously we established an arthritis-prone FcγRIIB-deficient mouse strain (designated KO1). Anti-mouse CD11b mAb (5C6) has been reported to inhibit the recruitment of peripheral CD11b(+) myelomonocytic cells from the blood to the inflammatory site. These cells include neutrophils and m...

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Veröffentlicht in:Arthritis Res Ther
Hauptverfasser: Ohtsuji, Mareki, Lin, Qingshun, Okazaki, Hideki, Takahashi, Kazuko, Amano, Hirofumi, Yagita, Hideo, Nishimura, Hiroyuki, Hirose, Sachiko
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5806351/
https://ncbi.nlm.nih.gov/pubmed/29422084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-018-1523-1
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