Syndecan-2 Attenuates Radiation-induced Pulmonary Fibrosis and Inhibits Fibroblast Activation by Regulating PI3K/Akt/ROCK Pathway via CD148

Radiation-induced pulmonary fibrosis is a severe complication of patients treated with thoracic irradiation. We have previously shown that syndecan-2 reduces fibrosis by exerting alveolar epithelial cytoprotective effects. Here, we investigate whether syndecan-2 attenuates radiation-induced pulmonar...

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Veröffentlicht in:Am J Respir Cell Mol Biol
Hauptverfasser: Tsoyi, Konstantin, Chu, Sarah G., Patino-Jaramillo, Nasly G., Wilder, Julie, Villalba, Julian, Doyle-Eisele, Melanie, McDonald, Jacob, Liu, Xiaoli, El-Chemaly, Souheil, Perrella, Mark A., Rosas, Ivan O.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Thoracic Society 2018
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5805997/
https://ncbi.nlm.nih.gov/pubmed/28886261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2017-0088OC
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