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Inhibition of T-cell Activation by Syndecan-4 Is Mediated by CD148 Through Protein Tyrosine Phosphatase Activity
Most coinhibitory receptors regulate T cell responses through an immunoreceptor tyrosine-based inhibitory motif (ITIM) that recruits protein tyrosine phosphatases (PTP) to mediate inhibitory function. Because syndecan-4 (SD-4), the coinhibitor for DC-HIL, lacks such an ITIM, we posited that SD-4 lin...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3128389/ https://ncbi.nlm.nih.gov/pubmed/21469128 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201041233 |
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