RAGE-aptamer attenuates deoxycorticosterone acetate/salt-induced renal injury in mice

The mineralocorticoid receptor (MR) and its downstream signaling play an important role in hypertensive renal injury. The interaction of advanced glycation end products (AGE) with their receptor (RAGE) is involved in the progression of renal disease. However, the pathological crosstalk between AGE–R...

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Published in:Sci Rep
Main Authors: Taguchi, Kensei, Yamagishi, Sho-ichi, Yokoro, Miyuki, Ito, Sakuya, Kodama, Goh, Kaida, Yusuke, Nakayama, Yosuke, Ando, Ryotaro, Yamada-Obara, Nana, Asanuma, Katsuhiko, Matsui, Takanori, Higashimoto, Yuichiro, Brooks, Craig R., Ueda, Seiji, Okuda, Seiya, Fukami, Kei
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5805738/
https://ncbi.nlm.nih.gov/pubmed/29422652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-21176-5
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