DNA Aptamer Raised Against AGEs Blocks the Progression of Experimental Diabetic Nephropathy

Advanced glycation end products (AGEs) and their receptor (RAGE) play a role in diabetic nephropathy. We screened DNA aptamer directed against AGEs (AGEs-aptamer) in vitro and examined its effects on renal injury in KKAy/Ta mice, an animal model of type 2 diabetes. Eight-week-old male KKAy/Ta or C57...

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Detalhes bibliográficos
Main Authors: Kaida, Yusuke, Fukami, Kei, Matsui, Takanori, Higashimoto, Yuichiro, Nishino, Yuri, Obara, Nana, Nakayama, Yosuke, Ando, Ryotaro, Toyonaga, Maki, Ueda, Seiji, Takeuchi, Masayoshi, Inoue, Hiroyoshi, Okuda, Seiya, Yamagishi, Sho-ichi
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3749365/
https://ncbi.nlm.nih.gov/pubmed/23630304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-1608
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