The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma

Circulating CCR2(+) monocytes are crucial for maintaining the adult tissue-resident F4/80(hi)MHCII(hi) macrophage pool in the intestinal lamina propria. Here we show that a subpopulation of CCR2-independent F4/80(hi)MHCII(low) macrophages, which are the most abundant F4/80(hi) cells in neonates, gra...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Soncin, Irene, Sheng, Jianpeng, Chen, Qi, Foo, Shihui, Duan, Kaibo, Lum, Josephine, Poidinger, Michael, Zolezzi, Francesca, Karjalainen, Klaus, Ruedl, Christiane
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5805689/
https://ncbi.nlm.nih.gov/pubmed/29422500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-02834-8
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