Reverting iodine avidity of radioactive-iodine refractory thyroid cancer with a new tyrosine kinase inhibitor (K905-0266) excavated by high-throughput NIS (sodium iodide symporter) enhancer screening platform using dual reporter gene system

Radioactive-iodine (RAI) therapy is typically unprevailing as anaplastic thyroid cancer (ATC) management, owing to the decrease in the endogenous sodium iodide symporter (NIS) expression. Therefore, new strategies for NIS re-induction are required to improve the efficacy of RAI therapy in ATC. In th...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Oh, Ji Min, Kalimuthu, Senthilkumar, Gangadaran, Prakash, Baek, Se Hwan, Zhu, Liya, Lee, Ho Won, Rajendran, Ramya Lakshmi, Hong, Chae Moon, Jeong, Shin Young, Lee, Sang-Woo, Lee, Jaetae, Ahn, Byeong-Cheol
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2018
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5805537/
https://ncbi.nlm.nih.gov/pubmed/29467951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24159
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