Global transcriptional silencing and developmental competence in the oocyte mediated by the mRNA decay activator ZFP36L2

Global transcriptional silencing is a highly conserved mechanism central to the oocyte-to-embryo transition. We report the unexpected discovery that global transcriptional silencing in oocytes depends on an mRNA decay activator. Oocyte-specific loss of ZFP36L2—an RNA-binding protein critical for AU-...

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Pubblicato in:Dev Cell
Autori principali: Chousal, Jennifer N., Cho, Kyucheol, Ramaiah, Madhuvanthi, Skarbrevik, David, Mora-Castilla, Sergio, Stumpo, Deborah F., Lykke-Andersen, Jens, Laurent, Louise C., Blackshear, Perry F., Wilkinson, Miles F., Cook-Andersen, Heidi
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5805474/
https://ncbi.nlm.nih.gov/pubmed/29408237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2018.01.006
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