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Challenges in validating candidate therapeutic targets in cancer

More than 30 published articles have suggested that a protein kinase called MELK is an attractive therapeutic target in human cancer, but three recent reports describe compelling evidence that it is not. These reports highlight the caveats associated with some of the research tools that are commonly...

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Enregistré dans:
Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Settleman, Jeffrey, Sawyers, Charles L, Hunter, Tony
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5805407/
https://ncbi.nlm.nih.gov/pubmed/29417929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.32402
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