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Ligand binding modulates the structural dynamics and activity of urokinase-type plasminogen activator: A possible mechanism of plasminogen activation

The catalytic activity of trypsin-like serine proteases is in many cases regulated by conformational changes initiated by binding of physiological modulators to exosites located distantly from the active site. A trypsin-like serine protease of particular interest is urokinase-type plasminogen activa...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Kromann-Hansen, Tobias, Lange, Eva Louise, Lund, Ida K., Høyer-Hansen, Gunilla, Andreasen, Peter A., Komives, Elizabeth A.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5805342/
https://ncbi.nlm.nih.gov/pubmed/29420634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0192661
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