Divalent cations are dispensable for binding to DNA of a novel positively charged olivomycin A derivative

The current model of binding of the antitumor antibiotic olivomycin A (1) to GC-rich DNA regions presumes that coordination of the magnesium divalent cation with drug dimers is necessary for binding of 1 into the minor groove of the DNA duplex. Previously we have synthesized the derivatives of 1 ter...

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Veröffentlicht in:PLoS One
Hauptverfasser: Beniaminov, Artemy D., Dezhenkova, Lyubov G., Mamaeva, Olga K., Shchyolkina, Anna K., Tevyashova, Anna N., Kaluzhny, Dmitry N., Shtil, Alexander A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5805246/
https://ncbi.nlm.nih.gov/pubmed/29420558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0191923
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