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Divalent cations are dispensable for binding to DNA of a novel positively charged olivomycin A derivative
The current model of binding of the antitumor antibiotic olivomycin A (1) to GC-rich DNA regions presumes that coordination of the magnesium divalent cation with drug dimers is necessary for binding of 1 into the minor groove of the DNA duplex. Previously we have synthesized the derivatives of 1 ter...
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| 出版年: | PLoS One |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5805246/ https://ncbi.nlm.nih.gov/pubmed/29420558 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0191923 |
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