Ethyl pyruvate ameliorates hepatic injury following blunt chest trauma and hemorrhagic shock by reducing local inflammation, NF-kappaB activation and HMGB1 release

BACKGROUND: The treatment of patients with multiple trauma including blunt chest/thoracic trauma (TxT) and hemorrhagic shock (H) is still challenging. Numerous studies show detrimental consequences of TxT and HS resulting in strong inflammatory changes, organ injury and mortality. Additionally, the...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Wagner, Nils, Dieteren, Scott, Franz, Niklas, Köhler, Kernt, Mörs, Katharina, Nicin, Luka, Schmidt, Julia, Perl, Mario, Marzi, Ingo, Relja, Borna
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5805235/
https://ncbi.nlm.nih.gov/pubmed/29420582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0192171
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